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-Results from ENTRATA Phase 2 trial of telaglenastat in patients with advanced renal cell carcinoma (RCC) accepted as Late Breaking Oral Presentation-
-Data from INCB001158 clinical program accepted as Oral Presentation-
SOUTH SAN FRANCISCO, Calif., Sept. 03, 2019 (GLOBE NEWSWIRE) -- Calithera Biosciences, Inc. (Nasdaq: CALA), a clinical stage biotechnology company focused on discovering and developing novel small molecule drugs for the treatment of cancer and other life-threatening diseases, today announced that new data from two oncology programs have been selected for oral presentations at the European Society for Medical Oncology (ESMO) 2019 Congress to be held September 27-October 1, in Barcelona, Spain.
The late-breaking abstract (#LBA54) titled, “ENTRATA: Randomized, double-blind, phase 2 study of telaglenastat (CB-839) + everolimus vs. placebo + everolimus in patients with advanced/metastatic renal cell carcinoma (RCC),” has been selected for oral presentation as part of a session titled, “Proffered Paper 1-Genitourinary tumors, non-prostate” on September 28, 2019, at 8:30 a.m. CET in Barcelona Auditorium (Hall 2). The oral presentation will be led by Chung-Han Lee of the Memorial Sloan Kettering Cancer Center, New York, NY.
The oral abstract (#440O) titled, “Phase 1 study of the arginase inhibitor INCB001158 (1158) alone and in combination with pembrolizumab in patients with advanced/metastatic solid tumors,” has been accepted for oral presentation as part of a session titled, “Proffered Paper – Developmental therapeutics,” on September 29, 2019, at 4:30 p.m. CET in the Malaga Auditorium (Hall 5). The oral presentation will be led by Aung Naing, M.D., FACP, Associate Professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
“We look forward to presenting data from the ENTRATA trial, for which positive topline results were announced earlier this year, as well as new data from our clinical program partnered with Incyte that is evaluating the arginase inhibitor INCB001158 in solid tumors,” said Susan Molineaux, Ph.D., president and chief executive officer at Calithera. “We remain committed to advancing our robust pipeline, including our lead compound telaglenastat for which the registrational CANTATA trial in RCC is underway and expected to readout in the second half of 2020.”
Telaglenastat is an investigational first-in-class, novel glutaminase inhibitor specifically designed to block glutamine consumption in tumor cells. RCC tumors commonly exhibit metabolic alterations that increase their dependence on glutamine. In preclinical studies, telaglenastat produced synergistic antitumor effects when used in combination with standard-of-care RCC therapies. The randomized Phase 2 ENTRATA trial of telaglenastat plus everolimus versus everolimus plus placebo met its primary endpoint of improving progression free survival, demonstrating proof of concept for telaglenastat in patients with advanced RCC. The ongoing CANTATA trial is a global, randomized, double-blind trial designed to evaluate the safety and efficacy of telaglenastat plus cabozantinib versus placebo plus cabozantinib in patients with advanced or metastatic RCC.
About INCB001158 (CB-1158)
INCB001158 (CB-1158) is an investigational first-in-class, novel small molecule arginase inhibitor. Arginase is an enzyme that suppresses the immune-mediated destruction of tumors by depleting levels of a key amino acid, L-arginine, from the tumor microenvironment. A number of cell types in the tumor microenvironment, including myeloid-derived suppressor cells, macrophages, and neutrophils, can secrete arginase. L-arginine deprivation can act via nutrient sensor pathways to exert several suppressive effects on T-cell function, inhibiting proliferation, decreasing cytokine production, and diminishing expression of the T-cell receptor CD3ζ chain. Arginase activity may thus impair T-cell mediated anti-tumor responses. INCB001158 is being developed in a global collaboration with Incyte Corporation.
Calithera Biosciences is a clinical-stage biopharmaceutical company pioneering the discovery and development of targeted therapies that disrupt cellular metabolic pathways to preferentially block tumor cells and enhance immune-cell activity. Driven by a commitment to rigorous science and a passion for improving the lives of people impacted by cancer and other life-threatening diseases, Calithera is advancing a pipeline of first-in-clinic, oral therapeutics to meaningfully expand treatment options available to patients. Calithera is headquartered in South San Francisco, California. For more information about Calithera, please visit www.calithera.com.
Forward Looking Statements
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SOURCE: Calithera Biosciences, Incorporated